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KMID : 1161520200240050243
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Animal Cells and Systems
2020 Volume.24 No. 5 p.243 ~ p.252
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CD47 (Cluster of differentiation 47): an anti-phagocytic receptor with a multitude of signaling functions
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Leclair Pascal
Lim Chinten James
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Abstract
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CD47 is a tumor-associated antigen best known for its ability to bind counter-receptors on the surface of professional phagocytes as an immune-evasion strategy. ?Recently, CD47 has been shown to play a role as a signaling receptor, involving a number of cell physiological processes.?? This review provides a comprehensive survey of the signaling pathways triggered by CD47 ligand-mediated cell death in tumor cells. Such an understanding should lead to improvement of CD47-targeted anti-tumor therapeutics able to both neutralize the anti-phagocytic role and trigger autonomous tumor cell death.
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KEYWORD
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CD47, phagocytosis, cell death, antibodies, peptides
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